Pain 45+ is a combination of potent and patented herbal extracts that help combat acute and chronic pain and inflammation through inhibiting inflammatory enzymes. What makes this product unique is that it is multifunctional : it inhibits the processes responsible for pain and inflammation, and in addition has calmative effects that aid to mitigate the stress that accompanies pain. This product is a safe, effective alternative to NSAIDs (non-steroidal anti-inflammatory drugs) with effects apparent in under a week (2-5 days). Moreover, the Curcumin (C3 Complex) in this product is the most extensively studied form of Curcumin on the market, with over 80 publications verifying safety and efficacy ensuring the most reliable, and safe form of Curcumin .
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Perluxan ® is a patented hops extract that uses super critical fluids (an extraction process used to strip away unwanted Hops constituents and keep just the Alpha Acids which have anti-pain and inflammation properties). This part of Pain 45+ acts fast, relieving joint discomfort within two hours of ingestion.
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Boswellin Super ® is a patented extract of Boswellia. Its effects are predominant in the joints and is highly effective for osteoarthiritus with little cox inhibition (but seems to act on Lypooxigenase (LOX Inhibition)).

We use a 30% AKBBA (Acetyl-11-keto-beta-boswellic acid) extract, which amongst the Boswellic Acids, is the most effective in reducing inflammation and pain based on many clinical studies. Many companies will put BA (Boswellic Acids) and in a high concentration. But you will not know what part of that is AKBBA (or AKBA which is synonymous), which is the most effective at
pain and inflammation. It’s akin to a proprietary blend where you don’t know what proportion of the blend is what.
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Devils Claw is widely used in Germany, France and throughout other areas of Europe. It is very effective for osteoarthritic pain, and back pain (anti-inflammatory) by acting on COX enzymes by Harpogoside compounds in Devils Claw. This is slowest acting anti-inflammatory of all the ingredients (works best with consistent administration (vs. Perluxan which works quick)
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Lastly, Gingerol is the active compound in ginger, related to Capsaicin and Piperine (black pepper alkaloid that is beneficial for increased bioavailability). Gingerol is used for its anti-inflammatory effect as it affects inflammatory messenger proteins (eg. cytokines) and inflammatory enzymes such as COX. It is also a powerful antioxidant.
 
Recommended dose: Adults take 2 capsules one time daily and continue for best results. After a period of time when satisfied with results, the dosage can be decreased to one capsule for maintenance.
 
NPN:80046588